1. Patient swallow urea capsule labeled with ¹³C/¹⁴C.
2. If the patient is infected with H. pylori, orally administered ¹³C/¹⁴C-Urea will be hydrolyzed into ammonia and ¹³CO₂/¹⁴CO₂.
3. ¹³CO₂/¹⁴CO₂ is absorbed into the blood circulation and exhaled by the lung.
4. Collect the pre-dose and post-dose exhale breath and analyze the variation of ¹³C/¹²C ratio in exhaled CO₂ to diagnose the infection of H. pylori (¹³C-Urea Breath Test) .
Collect the exhale breath and test it. The presence of a significant amount of ¹⁴CO₂ in the exhaled breath indicates active H. pylori infection (¹⁴C-Urea Breath Test) .